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Book Fas Ligand reverse signaling: an immunmodulatory setscrew: Insights gained from ?knockout/knockin' mice that express a functional Fas Ligand molecule lacking the intracellular domain

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Fas Ligand reverse signaling: an immunmodulatory setscrew: Insights gained from ?knockout/knockin' mice that express a functional Fas Ligand molecule lacking the intracellular domain

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    Available in PDF - DJVU Format | Fas Ligand reverse signaling: an immunmodulatory setscrew: Insights gained from ?knockout/knockin' mice that express a functional Fas Ligand molecule lacking the intracellular domain.pdf | Language: ENGLISH
    Katharina Lückerath (Author)

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Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ('reverse signaling'). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL?Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases.
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Book details

  • PDF | 144 pages
  • Katharina Lückerath (Author)
  • Suedwestdeutscher Verlag fuer Hochschulschriften (7 April 2011)
  • English
  • 5
  • Science Nature

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